Activation of muscle fibers in individual motor units revealed by 2- deoxyglucose-6-phosphate
نویسندگان
چکیده
منابع مشابه
Activation of muscle fibers in individual motor units revealed by 2-deoxyglucose-6-phosphate.
Motor units of the cat tibialis posterior muscle were selectively activated by prolonged electrical stimulation of functionally isolated motor axons in situ. During the activation, the glucose analog 2-deoxyglucose (DG) was administered systemically. Single muscle fibers were subsequently examined for accumulation of the metabolite 2-deoxyglucose-6-phosphate (DG6P) by an analytical assay and fo...
متن کاملStructure and function of muscle fibers and motor units
Introduction The term “motor unit” was introduced by Sir Charles Sherrington, a founder of modern neurophysiology, who observed that force occurred in discrete steps when a muscle contracted in the stretch reflex [1]. He postulated that each step was produced by the all-or-none action of a single motor neuron upon the muscle fibers it innervated. Sherrington’s concept of the motor unit assumed ...
متن کاملMechanisms of reduced SR Ca(2+) release induced by inorganic phosphate in rat skeletal muscle fibers.
The effects of inorganic phosphate (P(i)) on Ca(2+) release from the sarcoplasmic reticulum (SR) were studied in mechanically skinned rat skeletal muscle fibers. Application of caffeine or T-tubule depolarization was used to induce Ca(2+) release from the SR, which was detected using fura 2 fluorescence. Addition of P(i) (1-40 mM) caused a reversible and concentration-dependent reduction in the...
متن کاملTask Dependent Synchronization of Motor Units of the Medial Gastrocnemius Muscle Revealed in EMG-Currents
Human movements have to be very tightly controlled by the neuro-muscular control mechanisms. In free style ski jumps the muscular events were as short as or shorter than 50ms and inter muscular co-contractions started and were synchronized within a time range of less than 5ms [1]. The Piper rhythm shows a neuromuscular control mechanism that can be seen in the EMG during isometric contractions ...
متن کاملSphingomyelinase stimulates 2-deoxyglucose uptake by skeletal muscle.
The effects of sphingomyelinase, phosphorylcholine, N-acetylsphingosine (C2-ceramide), N-hexanoylsphingosine (C6-ceramide) and sphingosine on basal and insulin-stimulated cellular accumulation of 2-deoxy-D-glucose in rat soleus muscles were investigated. Preincubation of muscles with sphingomyelinase (100 or 200 m-units/ml) for 1 or 2 h augmented basal 2-deoxyglucose uptake by 29-91%, and that ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1988
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.08-11-03959.1988